Two sample MR report
STXBP2_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.1945762 | 0.5035978 | 0.7652761 |
| Weighted median | 3 | -0.1032509 | 0.0372880 | 0.0056226 |
| Inverse variance weighted | 3 | -0.1019969 | 0.0304242 | 0.0008009 |
| Simple mode | 3 | -0.1045001 | 0.0422845 | 0.1320609 |
| Weighted mode | 3 | -0.1056275 | 0.0418084 | 0.1274045 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0272312 | 1 | 0.8689293 |
| Inverse variance weighted | 0.0611506 | 2 | 0.9698874 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0553234 | 0.3003892 | 0.8840516 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.53e-05 | 0 | TRUE | 0.5273834 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
